more>SIPCD Snapshots

Invited Speakers

Muthiah (Mano) Manoharan

Muthiah (Mano) Manoharan, Ph.D, 

Senior Vice President of Alnylam Pharmaceuticals, USA

Dr. Muthiah (Mano) Manoharan serves as  a Senior Vice President of Drug Innovation, a  Scientific Advisory Board Member, and a Distinguished Research Scientist at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA. Dr. Manoharan has had a distinguished career as a world-leading chemist in the areas of oligonucleotide chemical modifications, conjugation chemistry, and delivery platforms (lipid nanoparticles, polymer conjugates, and complex-forming strategies).  Dr. Manoharan and his research group designed, synthesized and demonstrated for the first time the human therapeutic applications of GalNAc-conjugated oligonucleotides at Alnylam, a platform that has revolutionized the nucleic acid-based therapeutics field with several compounds presently in the advanced clinical trials.  He is an author of more than 215 publications (nearly 44,000 Google Scholar citations with an h-index of 96 and an i10-index of 375) and over 400 abstracts, as well as an inventor of over 240 issued U.S. patents.  

Prior to Alnylam, Dr. Manoharan worked at Ionis  (formerly Isis) Pharmaceuticals and  LifeCodes Corporation in the field of antisense oligonucleotide therapeutics.

Dr. Manoharan earned his Ph.D. in chemistry at the University of North Carolina, Chapel Hill with Professor Ernest Eliel in Organic Chemistry.  He started working in the field of oligonucleotides at Yale University as a post-doctoral research associate with Professor John Gerlt.

Dr. Manoharan has been recognized as the Lifetime Achievement Awardee of the Oligonucleotide Therapeutics Society for the year 2019.  He received the M. L. Wolfrom Award from the American Chemical Society in 2007.


1.      Manoharan, M.: Curr. Opin. Chem. Biol., 2004, 8, 570-579.

2.      Soutschek, al; Nature 2004, 432, 173-178.

3.      Kruetzfeldt, al; Nature 2005, 438, 685-689.

4.      Bumcrot, D., et al.: Nature Chem. Biol., 2006, 2, 711-719.

5.      Zimmermann, T. et al; Nature 2006, 441, 111-114.

6.      Wolfrum, C. et al; Nat. Biotech. 2007, 25, 1149-1157.

7.      Manoharan, M., Rajeev, K. G.: Antisense Drug Technology, 2008, 437-464.

8.    Jayaraman, M.; et al., Angew. Chem. Int. Ed. 2012, 51, 8529-8533.  

9.    Maier, M.A.; et al.,  Mol. Ther. 201321, 1570-1578.

10.  Nair, J.K., et al.: J. Am. Chem. Soc., 2014, 136, 16958-61.

11.  Matsuda, S., et al.: ACS Chem. Biol., 2015, 10, 1181-1187.

12.  Rajeev, K.G., et al.: ChemBioChem, 2015, 16, 903-908.

13.  Elkayam, E., et al.: Nucleic Acids Res., 2016, 45, 3528-3536.

14.  Schlegel, M..K., et al.: J. Am. Chem. Soc., 2017, 139, 8537-8546.

15.  Janas, M. M.; Schlegel, M..K., et al., Nature Commun. 2018, 9, 723.

16.  Parmar, R. G.; et al. J. Med. Chem. 2018, 61, 734-744.

17.  Zlatev, I et al, Nature Biotech 2018, 36, 509-511.

18.  Egli, M. and Manoharan, M. (2019) Accounts of Chemical Research, 52, 1036-1047.


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