more>SIPCD Snapshots

Invited Speakers



Julien Nicolas

Julien Nicolas

 

CNRS Director of Research

Institut Galien Paris-Sud, UMR CNRS 8612, Faculty of Pharmacy

Châtenay-Malabry

France

 

Group Website:

http://julnicolas.free.fr

 

 

Julien Nicolas obtained a Master degree in Chemical Engineering in 2001 from Ecole Supérieure de Chimie Organique et Minérale (ESCOM), in Cergy-Pontoise, France and a Master degree in Polymer Chemistry in 2002 from the Université Pierre et Marie Curie (UPMC), Paris, France. He then completed his PhD in 2005 under the supervision of Prof. Bernadette Charleux at UPMC, where he studied nitroxide-mediated polymerization in aqueous dispersed media. He then joined the group of Prof. David M. Haddleton at the University of Warwick (UK) as a postdoctoral researcher, where he worked in the field of polymer-protein bioconjugates. In 2007, he obtained a permanent CNRS researcher position at Institut Galien Paris-Sud (Univ. Paris-Sud) in Châtenay-Malabry, France, in the group of Prof. Patrick Couvreur. In 2016, he got promoted CNRS Director of research.

His current research activities lie in advanced macromolecular synthesis and in the design of innovative polymer-based nanomedicines including block copolymer nanoparticles, polymer prodrug nanoparticles and other innovative polymer-based biomaterials.

He is (co)author of more than 85 peer review articles in international journals, 7 patents and 13 book chapters (h-index 37 and number of citations 6700). He is Associate Editor for Chemistry of Materials (ACS) and is part of the Editorial Advisory Board of Polymer Chemistry (RSC) and Regenerative Biomaterials (Oxford Academic). He received the 2016 SCF/GFP award and the 2017 Polymer Chemistry Lectureship award

 

Representative Publications

[1]  Tardy, A.; Honoré, J.-C.; Tran, J.; Siri, D.; Delplace, V.; Bataille, I.; Letourneur, D.; Perrier, J.; Nicoletti, S.; Maresca, M.; Lefay, C.; Gigmes, D.; Nicolas, J.;* Guillaneuf, Y.* Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters. Angew. Chem., Int. Ed. 2017, 56, 16515

[2]  Bao, Y.; Boissenot, T.; Guégain, E.; Desmaële, D.; Mura, S.; Couvreur, P.; Nicolas, J.* Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tuneable Drug Delivery Properties. Chem. Mater. 2016, 28, 6266

[3]  Nicolas, J.* Drug-Initiated Synthesis of Polymer Prodrugs: Combining Simplicity and Efficacy in Drug Delivery. Chem. Mater. 2016, 28, 1591

[4]  Delplace, V.; Nicolas, J.* Degradable Vinyl Polymers for Biomedical Applications. Nature Chem. 2015, 7, 771

[5]  Delplace, V.; Guégain, E.; Harrisson, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* A Ring to Rule Them All: A Cyclic Ketene Acetal Comonomer Controls the Nitroxide-Mediated Polymerization of Methacrylates and Confers Tunable Degradability. Chem. Commun. 2015, 51, 12847

[6]  Mackiewicz, N.; Nicolas, J.;* Handké, N.; Noiray, M.; Mougin, J.; Daveu, C.; Reddy, L. H.; Bazile, D.; Couvreur, P. Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Chem. Mater. 2014, 26, 1834

[7]  Mura, S.; Nicolas, J.; Couvreur, P.* Stimuli-Responsive Nanocarriers for Drug Delivery. Nature Mater. 2013, 12, 991

[8] Harrisson, S.; Nicolas, J.;* Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization. Angew. Chem., Int. Ed. 2013, 52, 1678

[9]  Nicolas, J.;* Guillaneuf, Y.;* Lefay, C.; Bertin, D.; Gigmes, D.; Charleux, B. Nitroxide-Mediated Polymerization. Prog. Polym. Sci. 2013, 38, 63

[10]  Le Droumaguet, B.; Nicolas, J.;* Brambilla, D.; Mura, S.; Maksimenko, A.; De Kimpe, L.; Salvati, E.; Zona, C.; Airoldi, C.; Canovi, M.; Gobbi, M.; Noiray, M.; La Ferla, B.; Nicotra, F.; Scheper, W.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. Versatile and Efficient Targeting from a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. ACS Nano 2012, 6, 5866


Soochow University Biomedical Polymers Laboratory 
199 Ren-Ai Road, Suzhou Industrial Park, Suzhou 215123, China