UT Southwestern Medical Center
Jinming Gao is a Professor of Oncology, Pharmacology and Otolaryngology in the Simmons Cancer Center at UT Southwestern Medical Center. He graduated with a BS degree in chemistry from Beijing University. He received his PhD from George Whitesides at Harvard and postdoc training at MIT with Bob Langer. Dr. Gao has published over 120 peer-reviewed papers (citations>20,000 and h-index >60). He has received multiple awards including the Outstanding Scientist Award from the Society for Experimental Biology and Medicine. He was the Chair of Gene and Drug Delivery study section at the NIH. His lab recently invented a series of pH nanotransistors for cancer imaging, drug delivery and cancer immunotherapy. He co-founded OncoNano Medicine, a startup company focusing on the translation of tumor-activatable nanoprobes for image-guided cancer surgery. Its first clinical product is reaching first-in-human trial in early 2018 for various cancer indications. Using a highly-interdisciplinary approach, Dr.Gao’s lab is developing and applying new biotransistor technology for digital medicine applications.
(1) Wang Y et al. A Nanoparticle-based Strategy for the Imaging of a Broad Range of Tumours by Nonlinear Amplification of Microenvironment Signals. Nat. Mater. 2014, 13, 204-212.
(2) Wang C et al. A Nanobuffer Reporter Library for Fine-Scale Imaging and Perturbation of Endocytic Organelles. Nature Comm. 2015, 6, 8524.
(3) Yang L et al. Molecular Basis of pH-Triggered Molecular Self-Assembly. Nature Comm. 2016, 7, 13214.
(4) Zhao T et al. A Transistor-like pH Nanoprobe for Tumour Detection and Image-Guided Surgery. Nature BME, 2016, 1, 0006.
(5) Luo M et al. STING-Activating Nanovaccine for Cancer Immunotherapy. Nature Nanotech. 2017, 12, 648-654.
(6) Wang C et al. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nature Comm. 2018, 8, 2270.